World AIDS Day, celebrated on December 1st, aims to unite people globally in the fight against HIV and AIDS. A group significantly affected by this disease is the transgender community, who face a rate of HIV/AIDS double that of cisgender sexual minorities. An alarming 28% of transgender women in urban US areas are estimated to have HIV, and transgender men represent 15% of new HIV diagnoses among transgender individuals nationally. The transgender community often faces barriers such as stigma, discrimination, and economic challenges, contributing to increased HIV risk. Moreover, legal frameworks that criminalize sex work and healthcare barriers, like a lack of understanding and cultural responsiveness, exacerbate these challenges. Particularly vulnerable are transgender people of color, especially Black transgender individuals, who experience intensified discrimination and marginalization. Addressing these disparities requires tailored HIV testing, prevention, and care strategies, including patient empowerment, improved healthcare provider competence, and innovative testing methods. On World AIDS Day, it’s imperative to spotlight communities like transgender people of color, who are disproportionately affected by HIV, ensuring they receive adequate resources and care.